Neural oscillations of spatial navigation and memory in human hippocampo-cortical circuits
報告人簡介
王亮，中國科學院心理研究所研究員，博士生導師，中國科學院心理健康重點實驗室主任，中國科學院大學心理學系崗位教授。擔任中國心理學會副秘書長、中國心理學會生理心理學專委會副主委、中國神經科學學會認知生物學分會副主委等。研究成果以通訊作者發表在Neuron,Science Advances（2篇）,Current Biology（2篇）,Annals of Neurology等權威期刊。
內容簡介
A growing body of studies have revealed many spatial cells in hippocampal formation, and similar brain activity patterns at the macroscopic level. With human intracranial EEG recordings, we found that theta power was hexadirectionally modulated by movement direction in the entorhinal cortex and medial prefrontal cortex. Inter-regional theta oscillations formed a synchronized hippocampo-cortical network, speeding up information transfer and facilitating memory-guided spatial navigation. Theta-based goal distance modulation and neural timescales gradually change along the hippocampal longitudinal axis, indicating a coarse-to-fine goal distance representation in the human hippocampus. Memory reactivation following learning of object-location associations increased hippocampal ripples and cortical spindles.
