Synthesis of penta- and tetra-fluorosulfanyl molecules for sustainable society
報告人簡介
Norio Shibata (born July 3, 1965) has been a professor of chemistry at Nagoya Institute of Technology since 2008. He received his Ph.D. (1993) in Pharmaceutical Sciences from Osaka University under the supervision of Professor Yasuyuki Kita. He worked at the Dyson Perrins Laboratory (Professor Sir Jack E. Baldwin) in Oxford University (JSPS Fellow, 1994-1996), Sagami Chemical Research Institute (Dr. Shiro Terashima, 1996), after which he was a lecturer at Toyama Medical & Pharmaceutical University (1997-2003) and an associate professor at Nagoya Institute of Technology (2003-2008). He received the“Takeda Pharmaceutical Company Award in Synthetic Organic Chemistry, Japan (2000)”, “Fujifilm Award in Synthetic Organic Chemistry, Japan (2003)”, “Incentive Award in Synthetic Organic Chemistry, Japan (2004)”, “RSC Fluorine Prize (inaugural prize in 2005)”, “20th Lecture Award for Young Chemists in Chemical Society of Japan (2005)”, “Fluorine Chemistry Research Incentive Award in Research Foundation ITSUU Laboratory (inaugural prize in 2009)”, “The Pharmaceutical Society of Japan Award for Divisional Scientific Promotions (2010)”, “Prizes for Science and Technology, The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology (2014)”, “CSJ Award for Creative Work in Chemical Society of Japan (2015)”, “Chinese Chemical Society, W.-Y. Huang Fluorine Prize (2015)”, International Scientific Partnership Foundation Award, the Gold Medals “CBC-2015. St. Petersburg (2015)”, “GLAXOSMITHKLINE LECTURE in Recent Advances in Synthesis and Chemical Biology XIV, Royal College of Surgeons in Ireland (2015), ““Certificate of Honor SUSTECH Chemical Science Lectureship in China (2017), ““Prof. B.D. Laroia Memorial Lecture Award from University of Delhi (2018)”, “Lecture Award in the International Congress on Pure & Applied Chemistry (ICPAC) 2018 (2018)”, “ACS Award for Creative Work in Fluorine Chemistry (2019)”, “The 18th (2018) Green and Sustainable Chemistry Awards by the Minister of Education, Culture, Sports, Science and Technology (2019), “The Society of Iodine Science Award (2019)”, “Fellow of Royal Society of Chemistry (2021, RSC, UK)” and “Chair of Excellence (LabEx SynOrg, France, 2022-2023)”. He is a Visiting Professor at the University of Rouen (2008, 2012) Academic Visitor at the University of Oxford (2017, 2018), University of Valencia (2017, 2019) , and Visiting Professor at the University of Münster (2024). Member of the ACS Fluorine Division Committee (2015-2017). Registered as an excellent reviewer by Publons (2021). His research interests cover a wide range of synthetic and medicinal fluorine chemistry.
內容簡介
The development of innovative synthetic methodologies for diversifying fluorinated structural motifs is crucial for drug discovery, as it expands the range of accessible molecules. Moreover, novel alternatives to popular fluorinated units, such as trifluoromethyl (-CF3) and difluoromethylene (-CF2-), have received increasing attention as environmentally benign fluorinated functional groups in the future market, as the use of molecules containing -CF3 and -CF2- is going to be discussed, such as PFAS. Particularly for agrochemical design, the use of CF3 and related fluorinated functional groups in drugs is controversial because of their degradation to highly acidic residues such as trifluoroacetic acid. In this context, lipophilic, hexacoordinate sulfur-fluorine analogs such as pentafluoro-sulfanyl (-SF5) and tetrafluoro-sulfanyl (-SF4-) units have received increasing attention as environmentally benign fluorinated functional groups. I will deliver a lecture on the recent progress in the synthesis of -SF5 and tetrafluoro-sulfanyl-SF4- units by our group.
