Optimal Transport for Latent Integration with An Application to Heterogeneous Neuronal Activity Data
報(bào)告人簡(jiǎn)介
Annie Qu is Chancellor’s Professor, Department of Statistics, University of California, Irvine. She received her Ph.D. in Statistics from the Pennsylvania State University in 1998. Qu’s research focuses on solving fundamental issues regarding structured and unstructured large-scale data and developing cutting-edge statistical methods and theory in machine learning and algorithms for personalized medicine, text mining, recommender systems, medical imaging data, and network data analyses for complex heterogeneous data. The newly developed methods can extract essential and relevant information from large volumes of intensively collected data, such as mobile health data. Her research impacts many fields, including biomedical studies, genomic research, public health research, social and political sciences. Before joining UC Irvine, Dr. Qu was a Data Science Founder Professor of Statistics and the Director of the Illinois Statistics Office at the University of Illinois at Urbana-Champaign. She was awarded the Brad and Karen Smith Professorial Scholar by the College of LAS at UIUC and was a recipient of the NSF Career award from 2004 to 2009. She is a Fellow of the Institute of Mathematical Statistics (IMS), the American Statistical Association, and the American Association for the Advancement of Science. She is also a recipient of IMS Medallion Award and Lecturer in 2024. She serves as Journal of the American Statistical Association Theory and Methods Co-Editor from 2023 to 2025 and as IMS Program Secretary from 2021 to 2027.
內(nèi)容簡(jiǎn)介
Detecting dynamic patterns of task-specific responses shared across heterogeneous datasets is an essential and challenging problem in many scientific applications in medical science and neuroscience. In our motivating example of rodent electrophysiological data, identifying the dynamical patterns in neuronal activity associated with ongoing cognitive demands and behavior is key to uncovering the neural mechanisms of memory. One of the greatest challenges in investigating a cross-subject biological process is that the systematic heterogeneity across individuals could significantly undermine the power of existing machine learning methods to identify the underlying biological dynamics. In addition, many technically challenging neurobiological experiments are conducted on only a handful of subjects where rich longitudinal data are available for each subject. The low sample sizes of such experiments could further reduce the power to detect common dynamic patterns among subjects. In this talk, we propose a novel heterogeneous data integration framework based on optimal transport to extract shared patterns in complex biological processes. The key advantages of the proposed method are that it can increase discriminating power in identifying common patterns by reducing heterogeneity unrelated to the signal by aligning the extracted latent spatiotemporal information across subjects. Our approach is effective even with a small number of subjects, and does not require auxiliary matching information for the alignment. In particular, our method can align longitudinal data across heterogeneous subjects in a common latent space to capture the dynamics of shared patterns while utilizing temporal dependency within subjects. Our numerical studies on both simulation settings and neuronal activity data indicate that the proposed data integration approach improves prediction accuracy compared to existing machine learning methods.
