報告人簡介：Bertrand Mollereau is a full professor and group leader at the LBMC (ENS of Lyon) since 2006. In 2017, he has been nominated for his outstanding career as a senior member of the Institut Universitaire de France. He is an internationally recognized expert in the fields of neurodegeneration, Parkinson's disease, autophagy, ER stress, cell death and lipid metabolism in Drosophila; he has published more than 60 publications on these topics. His lab uses Drosophila as a model of neurodegeneration and he has developed an extensive expertise on the measure of neurodegenerative hallmarks, including cell death by apoptosis and necrosis.
報告內(nèi)容介紹：Lipid metabolism dysregulation has been reported neurodegenerative disorders and in cancers. In these diseases, lipid storage organelles (lipid droplets, LDs) accumulate and function not only as lipid stores but also as dynamic regulators of the stress response. In Parkinson’s disease, the neuronal accumulation of alpha-synuclein (aSyn) aggregates and locomotor dysfunction are the hallmarks of the disease. Here, we used a Drosophila model in which aSyn is expressed in neurons to further elucidate LD and aSyn interactions and clarify whether LD per se contribute to the pathology. We show that expression of human aSyn induces progressive neuronal accumulation LD and that this in turn affect age-dependent aSyn aggregation. To further investigate the role of LDs in the process of cell death, we investigated the case of the physiological elimination of germ cells, which involves genetically controlled necrotic cell death during fly spermatogenesis. We have observed that LD accumulate in germ cell during the cell death process in germ cells. We are currently investigating the relationship between lipid droplet homeostasis and its interplay with non-apoptotic and apoptotic pathways in the control of germ cell elimination.
